Coating comprising an amorphous primer layer and a semi-crystalline reservoir layer

摘要

The present invention provides a coating comprising a reservoir layer comprising a semi-crystalline polymer and a primer layer comprising an amorphous polymer on an implantable device and methods of making and using the same.

主权项

1. An implantable device, comprising a coating comprising:
a reservoir layer comprising a biodegradable semi-crystalline polymer and a bioactive agent, and a primer comprising a biodegradable amorphous polymer; wherein the semi-crystalline polymer is selected from the group consisting of semi-crystalline poly(L-lactide-co-glycolide) (PLLA-GA) polymers with the content of L-lactide ranging from about 65 molar % to about 100 molar %, semi-crystalline poly(L-lactide-co-caprolactone) (PLLA-CL) (L-lactide/CL=75/25 by molar) polymer, semi-crystalline poly(L-lactide-co-caprolactone) (PLLA-CL) (L-lactide/CL=70/30 by molar) polymer, and combinations thereof; wherein the amorphous polymer has a miscibility of at least 5% in the semi-crystalline polymer; wherein the amorphous polymer comprises a polyester having a degradation rate faster than the semi-crystalline polymer; and wherein the coating has a degradation or absorption rate that within a period of 6 months after deployment of the implantable device, the coating has a mass loss of about 80% or more.