发明名称 |
Methods of treating hemoglobinopathies |
摘要 |
Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin H disease are provided. In some embodiments, the methods comprise administering an inhibitor selected from an ERK inhibitor, a MEK inhibitor, and a Raf inhibitor. Methods of inhibiting adhesion of sickle red blood cells to endothelial cells are also provided. |
申请公布号 |
US9592236(B2) |
申请公布日期 |
2017.03.14 |
申请号 |
US201214114456 |
申请日期 |
2012.04.30 |
申请人 |
DUKE UNIVERSITY |
发明人 |
Zennadi Rahima |
分类号 |
A61K31/5377;A61K31/166;A61K31/277;A61K31/18;A61K31/352;A61K31/404;A61K31/4412;A61K31/444 |
主分类号 |
A61K31/5377 |
代理机构 |
Andrus Intellectual Property Law, LLP |
代理人 |
Andrus Intellectual Property Law, LLP |
主权项 |
1. A method of alleviating vaso-occlusion in a patient with a hemoglobinopathy comprising administering to the patient a MEK inhibitor; wherein the patient has experienced at least one vaso-occlusive event, and wherein the MEK inhibitor is selected from U0126, PD98059, PD-334581, GDC-0973, CIP-137401, ARRY-162, ARRY-300, PD318088, PD0325901, CI-1040, BMS 777607, AZD8330, AZD6244, AS703026, RDEA119, and GSK1120212. |
地址 |
Durham NC US |