| 发明名称 | Potent anticancer activity via dual compound activation | ||
| 摘要 | The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods the use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other compounds and combinations of compounds. | ||
| 申请公布号 | US9592229(B2) | 申请公布日期 | 2017.03.14 |
| 申请号 | US201314382546 | 申请日期 | 2013.03.04 |
| 申请人 | The Board of Trustees of the University of Illinois;Vanquish Oncology, Inc. | 发明人 | Hergenrother Paul J.;Botham Rachel C.;Fan Timothy M.;Gilbert Mark J.;Handley Michael K.;Tarasow Theodore M. |
| 分类号 | A61K31/495;A61K31/437;A61K47/40;A61K9/00;A61K9/20;A61K9/48 | 主分类号 | A61K31/495 |
| 代理机构 | Haukaas Fortius PLLC | 代理人 | Haukaas Fortius PLLC ;Haukaas Michael H. |
| 主权项 | 1. A composition comprising (a) a compound of Formula (I):wherein R is H or Me; (b) the compound PAC-1:and (c) a pharmaceutically acceptable diluent, excipient, or carrier. | ||
| 地址 | Urbana IL US | ||