| 发明名称 |
Humanization of rabbit antibodies using a universal antibody framework |
| 摘要 |
The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications. |
| 申请公布号 |
US9593161(B2) |
申请公布日期 |
2017.03.14 |
| 申请号 |
US201414179141 |
申请日期 |
2014.02.12 |
| 申请人 |
ESBATech, an Alcon Biomedical Research Unit LLC |
发明人 |
Borras Leonardo Jose;Urech David |
| 分类号 |
C07K16/18;C07K16/22;C07K16/24 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An immunobinder comprising:
(i) light chain CDR1, CDR2 and CDR3 from a donor lagomorph immunobinder and heavy chain CDR1, CDR2 and CDR3 from a donor lagomorph immunobinder; (ii) a variable human light chain framework; and (iii) a variable human heavy chain framework that is at least 85% identical to the sequence of SEQ ID NO: 4 and comprises a threonine (T) at position 24, alanine (A) or glycine (G) at position 56, threonine (T) or asparagine (N) at position 84, and leucine (L) or valine (V) at position 89 (AHo numbering). |
| 地址 |
CH |
