主权项 |
1. A compound of formula I:where:
R1 is H, —C1-8alkyl, —CH(CH3)OC(O)—O-cyclohexyl, —(CH2)2-morpholinyl, or —CH2-5-methyl-[1,3]dioxol-2-one; R2 is —C0-3alkylene-NR22R23, R22 is H or —C1-6alkyl; R23 is H, —C1-6alkyl, —C1-6alkyl substituted with 1 to 6 fluoro atoms, —SO2—C1-6alkyl, —CH2OC(O)—C1-6alkyl, —C2-4alkylene-OH, —C2-4alkylene-O—CH3, or cyclopropyl optionally substituted with one or two R31 groups; or R22 and R23 are taken together to form —(CH2)2—O—(CH2)2—, a 2-oxa-6-aza-spiro[3.3]heptane ring, or an azetidine ring optionally substituted with one or two R31 groups; and each R31 is independently halo, —C1-6alkyl, —C0-2alkylene-OH, —C0-2alkylene-OC1-6alkyl, —CN, or —CONH2; R3, R4 and R5 are independently H or halo; R6 is a heterocycle selected from the group consisting of 3H-oxazol-2-one, [1,2,4]oxadiazol-5-one, [1,2,3,5]oxatriazole, dihydro-[1,2,4]triazol-3-one, [1,2,4]triazolo[1,5-α]pyridine, triazole, pyrazole, imidazole, oxazole, isoxazole, isothiazole, pyridine, oxadiazole, and pyrimidine; the heterocycle is attached at a carbon atom; and each nitrogen atom in the heterocycle is unsubstituted or substituted with an R60 group selected from the group consisting of —OH, —(CH2)2OH, —C0-2alkylene-O—C1-6alkyl, —C1-6alkyl, —CHF2, —CF3, and phenyl; and each carbon atom in the heterocycle is unsubstituted or substituted with an R61 group independently selected from the group consisting of halo, —OH, —C1-6alkyl, —C0-2alkylene-O—C1-6alkyl, —C(O)CH3, —C(O)NH(CH3), —C(O)N(CH3)2, —C3-6cycloalkyl, —CF3, —CH2SO2CH3, —NH2, —CH2NH2, —CH2N(CH3)2, pyrazine, and phenyl substituted with methyl or halo; or a pharmaceutically acceptable salt thereof. |