发明名称 |
Fascile synthesis of biocompatible polymer capsule nanoparticles for drug encapsulation |
摘要 |
The present invention relates to a method for preparing a capsule nanoparticle used in encapsulating hydrophobic medicines, comprising the following steps: (A) providing a biocompatible polymer and an organic solution containing a hydrophobic medicine; (B) stirring the organic solution at 3-10° C., and titrating with an alcohol solution, so as to make the biocompatible polymer encapsulate hydrophobic medicine to form a capsule nanoparticle; (C) ultrasonic vibrating the capsule nanoparticle at 3-10° C.; (D) filtering the capsule nanoparticle to an average size controllable in the range of 60-450 nm; and (E) lyophilizing the encapsulated particles. |
申请公布号 |
US9592205(B2) |
申请公布日期 |
2017.03.14 |
申请号 |
US201213624038 |
申请日期 |
2012.09.21 |
申请人 |
NATIONAL CHENG KUNG UNIVERSITY |
发明人 |
Shieh Dar-Bin |
分类号 |
A61K9/50;A61K9/51;A61K31/337;B82Y5/00 |
主分类号 |
A61K9/50 |
代理机构 |
Bacon & Thomas, PLLC |
代理人 |
Bacon & Thomas, PLLC |
主权项 |
1. A method for preparing capsules encapsulating hydrophobic medicines, comprising the steps of:
(A) providing an organic solution having a biocompatible polymer and a hydrophobic medicine; (B) stirring the organic solution at a low temperature of 3 to 10° C., and titrating with an alcohol solution, to make the biocompatible polymer encapsulate the hydrophobic medicine to form a capsule nanoparticle; (C) ultrasonic vibrating the capsule nanoparticle at a low temperature of 3 to 10° C.; (D) filtering the capsule nanoparticle, to make an average capsule nanoparticle diameter of the capsule nanoparticle at 60-450 nm; and (E) lyophilizing the capsule nanoparticle; Wherein the biocompatible polymer is selected from the group consisting (poly-(D,L-lactide-co-glycolide)), PLA, and PEG-PLA; and wherein the steps (A) to (E) are performed without surfactant. |
地址 |
TW |