Stabilized multi-functional antioxidant compounds and methods of use

摘要

Disclosed are novel stable compounds having anti-oxidant properties and methods of using the compounds for the treatment of diseases or injuries associated with oxidative stress.

主权项

1. A compound of Formula II:or a pharmaceutically acceptable salt thereof, wherein:wherein
L is —(CH2)m—; L1 is —CH(R5)—, or —C(═O)—; L2 is —O—, or —NH—; R4 is H, or C1-6 alkyl; R5 is H, —C(O)OH, or —C(═O)L2 R7; R6 is H, or —(CH2)nC(═O)R8; R7 is H, C1-6 alkyl, or —(CH2)pC(═O)OH; R8 is —OH, —CH3, —CH2C(═O)OH, or —(CH2)w—CH(NH2)—C(═O)OH; R9 is H, C1-6 alkyl, or —C(═O)C1-6 alkyl; m is 1, 2, 3, or 4; and n, p, and w, are each independently 0, 1, 2, 3, or 4.