发明名称 |
FREMGANGSMÅDER TIL BEHANDLING AF DISSEMINERET INTRAVASKULÆR KOAGULATION VED INHIBITION AF MASP-2-AFHÆNGIG KOMPLEMENTAKTIVERING |
摘要 |
In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. In one embodiment, the invention provides methods of treating a subject suffering from a complement mediated coagulation disorder, such as disseminated intravascular coagulation. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier. |
申请公布号 |
DK2488203(T3) |
申请公布日期 |
2017.03.13 |
申请号 |
DK20100824223T |
申请日期 |
2010.10.15 |
申请人 |
Omeros Corporation;University Of Leicester |
发明人 |
Schwaeble, Hans-Wilhelm;DUDLER, Thomas, A.;TEDFORD, Clark, E.;PARENT, James, B.;DEMOPULOS, Gregory, A. |
分类号 |
C07K16/40 |
主分类号 |
C07K16/40 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|