GENE EXPRESSION BASED BIOMARKER SYSTEM FOR IRRITABLE BOWEL SYNDROME (IBS) DIAGNOSIS

摘要

We have identified a suite of genes in a limited number of human colonic tissue samples with expression patterns that correlate with whether an individual is experiencing symptoms of Irritable Bowel Syndrome (IBS) (FIG. 2). Interestingly, in the efforts to screen for genes that might be used as biomarkers for IBS, it was found that no single gene could be used for this purpose. Instead, when examining the entire dataset, there exist signature gene expression patterns (e.g., fingerprints or biosignatures) of IBS that have use as a diagnostic tool for IBS.

主权项

1. A method of screening a genetic profile for genes associated with Irritable Bowel Syndrome (IBS), comprising:
obtaining a patient genetic profile from a sample of genetic material including a patient gene expression pattern, obtaining a control genetic profile from a control sample of genetic material including a control gene expression pattern; and comparing the patient gene expression pattern to the control gene expression pattern to identify a substantial presence of a gene expression pattern associated with irritable in the patient gene expression pattern.