| 发明名称 |
MICROSOMES IRREVERSIBLY INHIBITED FOR CYP450 THEIR USES IN THE PHENOTYPING OF ENZYMATIC METABOLIC PATHWAYS |
| 摘要 |
A method of preparing isolated microsomes comprising an irreversibly inhibited cytochrome P450 (CYP450). Isolated microsomes are characterized in that a cytochrome P450 thereof is irreversibly inhibited by a non-reversible inhibitor. The isolated microsomes according to the invention may be used in a method of phenotyping enzymatic reactions of a drug candidate. |
| 申请公布号 |
US2017067035(A1) |
申请公布日期 |
2017.03.09 |
| 申请号 |
US201615264786 |
申请日期 |
2016.09.14 |
| 申请人 |
LES LABORATOIRES SERVIER |
发明人 |
CARADEC Fabrice;PARMENTIER Yannick;POTHIER Corinne |
| 分类号 |
C12N9/02;C12Q1/26 |
主分类号 |
C12N9/02 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of preparing isolated microsomes comprising an irreversibly inhibited cytochrome P450 (CYP450), comprising the following steps;
a) irreversibly inhibiting a cytochrome P450; and b) concentrating the microsomal proteins. |
| 地址 |
SURESNES CEDEX FR |
