| 发明名称 |
MODIFIED CELLS AND METHODS OF THERAPY |
| 摘要 |
Genetically modified compositions, such as non-viral vectors and T cells, for treating cancer are disclosed. Also disclosed are the methods of making and using the genetically modified compositions in treating cancer. |
| 申请公布号 |
US2017065636(A1) |
申请公布日期 |
2017.03.09 |
| 申请号 |
US201615250514 |
申请日期 |
2016.08.29 |
| 申请人 |
Regents of the University of Minnesota ;Intima Bioscience, Inc. |
发明人 |
Moriarity Branden;Webber Beau;Choudhry Modassir |
| 分类号 |
A61K35/17;C07K14/47;C07K14/725;C12N5/0783 |
主分类号 |
A61K35/17 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating cancer, comprising: administering to a subject in need thereof a therapeutically effective amount of ex vivo engineered lymphocytes, wherein said ex vivo engineered lymphocytes comprise: a genomic alteration in a Cytokine Inducible SH2 Containing Protein (CISH) gene that results in suppression of CISH protein function in said ex vivo engineered lymphocytes. |
| 地址 |
Minneapolis MN US |
