发明名称 |
CHIMERIC AAV-ANTI-VEGF FOR TREATING CANCER IN CANINES |
摘要 |
Compositions and methods are provided for treating hemangiosarcoma in a subject. A recombinant AAV comprising a capsid and a vector genome comprising a nucleic acid expression cassette is provided. The expression cassette includes sequences encoding a promoter, a first signal peptide operably linked to an anti-VEGF antibody heavy chain immunoglobulin, a linker sequence, and a second signal peptide operably linked to an anti- VEGF light chain immunoglobulin, wherein said expression cassette co-expresses the immunoglobulin chains in a host cell under conditions which permit the chains to assemble into a functional anti-VEGF antibody. In one embodiment, the anti-VEGF antibody is a chimeric antibody. |
申请公布号 |
WO2017040528(A1) |
申请公布日期 |
2017.03.09 |
申请号 |
WO2016US49492 |
申请日期 |
2016.08.30 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
HINDERER, Christian;WILSON, James, M.;WILSON, Matthew |
分类号 |
A61K39/395;A61K48/00;C07H21/04;C12N15/00;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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