发明名称 |
Purinone derivative hydrochloride |
摘要 |
The purinone derivative 6-amino-9-[(3R)-1-(2 butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9 dihydro-8H-purin-8-one hydrochloride has Btk-selective inhibitory activity and, in addition to having excellent metabolic stability, it is a compound that exhibits a high level of solubility and absorption with respect to the free base and can be crystallized, hence it can serve as a therapeutic agent for diseases involving B cells and mast cells. |
申请公布号 |
AU2017201134(A1) |
申请公布日期 |
2017.03.09 |
申请号 |
AU20170201134 |
申请日期 |
2017.02.20 |
申请人 |
Ono Pharmaceuticals Co., Ltd. |
发明人 |
Yamamoto, Shingo;Yoshizawa, Toshio |
分类号 |
C07D473/34;A61K31/522;A61P7/02;A61P17/00;A61P29/00;A61P35/00;A61P35/02;A61P37/02;A61P37/08;A61P43/00 |
主分类号 |
C07D473/34 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|