ALCOHOL-RESISTANT ORAL PHARMACEUTICAL FORM

摘要

A sustained release oral pharmaceutical form suitable for single daily dose administration has a neutral microgranule coated with a mounting layer of active ingredient and pharmaceutically acceptable binder; and a coating layer of a hydrophobic coating polymer of a non-water soluble cellulose derivative, and at least 20% of inert load in relation to dry weight of hydrophobic coating polymer. The pharmaceutical form has improved resistance to rapid release of active ingredient, particularly in the presence of alcohol.

主权项

1. A method for avoiding or limiting immediate release of an active ingredient induced by the consumption of alcohol during the administration of a once a day sustained released pharmaceutical formulation, said method comprising administration of the pharmaceutical formulation comprising, from the center toward the periphery:
a neutral carrier, at least one mounting layer comprising an active ingredient and a pharmaceutically acceptable binder, a sustained-release coating layer comprising:
a hydrophobic coating polymer selected from non-water soluble cellulose derivatives, andat least 20% of an inert load in relation to the dry weight of the hydrophobic coating polymer.