COMPOSITION OF PALBOCICLIB OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL EXCIPIENT, AND PREPARATION METHOD THEREFOR

摘要

A composition of Palbociclib or a pharmaceutically acceptable salt thereof and a pharmaceutical excipient, and a preparation method therefor. Palbociclib or the pharmaceutically acceptable salt thereof is amorphous. The present invention further relates to a pharmaceutical composition containing a Palbociclib solid dispersion, comprising a solid dispersion formed by Palbociclib and an organic carrier and at least one pharmaceutical excipient, wherein Palbociclib is amorphous. The pharmaceutical composition of the present invention increases the dissolution rate of Palbociclib, and helps improve the bioavailability of medicine.