| 发明名称 |
THROMBIN-BINDING ANTIBODY MOLECULES AND USES THEREOF |
| 摘要 |
This invention relates to isolated antibodies which recognise the exosite 1 epitope of thrombin and selectively inhibit thrombin without promoting bleeding. These antibody molecules may be useful in the treatment and prevention of thrombosis, embolism and other conditions mediated by thrombin. |
| 申请公布号 |
US2017066842(A1) |
申请公布日期 |
2017.03.09 |
| 申请号 |
US201615348250 |
申请日期 |
2016.11.10 |
| 申请人 |
Janssen Pharmaceuticals, Inc. |
发明人 |
Huntington James Andrew;Baglin Trevor;Langdown Jonathan |
| 分类号 |
C07K16/40 |
主分类号 |
C07K16/40 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating or inhibiting a thrombin-mediated thrombosis or embolism, comprising administering to a patient in need thereof an antibody molecule that specifically binds to the exosite 1 region of thrombin and comprises a VH domain having the amino acid sequence of SEQ ID NO: 2 and a VL domain. |
| 地址 |
Titusville NJ US |
