ENZYME-ACTIVATED COLLAGEN AND TISSUE MATRICES

摘要

Devices and methods for treating defects in connective tissue are provided along with methods for making such devices. The devices can include enzyme-activated acellular tissue matrices that facilitate regrowth of the damaged tissue.

主权项

1. A method of treatment comprising:
selecting an anatomical site for treatment; selecting a collagen-based acellular tissue matrix, wherein the matrix has been contacted with a composition containing at least one protease, wherein the protease can cleave one or more matrikines from the tissue matrix, and wherein the composition further contains a deactivating agent comprising one or more chelators for reducing the activity of the at least one protease by binding metal ions needed for activity of the at least one protease; and implanting the collagen-based acellular tissue matrix into the anatomic site.