INTRALUMINAL PRESSURE DETECTION FOR DIVERTICULAR DISEASE

摘要

A pressure detection tablet is disclosed. The tablet is a capsule including a dye encapsulated within an inner coating, in which the inner coating is configured to rupture at a pressure equal to or greater than a pressure threshold. The tablet further includes an outer coating surrounding the capsule, in which the outer coating is configured to provide delivery of the capsule to a targeted site. The dye may be a non-metabolized, water soluble dye, such that a ruptured capsule releases the dye which can be visually detected in the urine. In some embodiments, the disclosure provides a method of making the tablet, using the tablet to detect peak pressure in the colon and reducing the risk of developing a colonic disorder.

主权项

1. A method for estimating a peak pressure within the colon of a subject, the method comprising:
providing a pressure detection tablet comprising a capsule, wherein the capsule comprises:
a water-soluble and non-metabolizable dye encapsulated within an inner coating, wherein the inner coating is configured to rupture at a pressure equal to or higher than a pressure threshold, andan outer coating surrounding the capsule, wherein the dye is absorbed by the colon and excreted by the kidneys in urine upon rupture of the inner coating; orally administering the pressure detection tablet to the subject; observing a color of the subject's urine after a test period; and estimating the peak pressure within the colon of the subject during the test period based on the color of the subject's urine.