发明名称 |
DNA GRIDIRON COMPOSITIONS AND METHODS |
摘要 |
Novel compositions and methods for engineering wireframe architectures and scaffolds of increasing complexity by creating gridiron-like DNA structures (FIG. 1). A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects, can be assembled according the methods presented herein. |
申请公布号 |
US2017066796(A1) |
申请公布日期 |
2017.03.09 |
申请号 |
US201515121007 |
申请日期 |
2015.02.25 |
申请人 |
Arizona Board of Regentson behalf of Azizona State University |
发明人 |
Han Dongran;Yan Hao |
分类号 |
C07H21/04;C07H1/00 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
|
主权项 |
1. A composition, comprising:
a plurality of immobile Holliday junction analogs linked together in a two-layer square frame in which the helices on opposite sides lie in the same plane. |
地址 |
Scottsdale AZ US |