发明名称 NEPRILYSIN INHIBITORS
摘要 In one aspect, the invention relates to compounds having the formula:;;where R1, R2a, R2b, R3-R6, a, b, Z, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
申请公布号 US2017066764(A1) 申请公布日期 2017.03.09
申请号 US201615270187 申请日期 2016.09.20
申请人 THERAVANCE BIOPHARMA R&D IP, LLC 发明人 Fleury Melissa;Gendron Roland;Hughes Adam D.;Smith Cameron
分类号 C07D471/04;A61K45/06;A61K31/42;C07D239/34;A61K31/505;C07D231/14;A61K31/415;C07D231/20;C07D249/04;A61K31/4192;C07D249/10;A61K31/4196;C07D249/18;A61K31/437;C07D261/18 主分类号 C07D471/04
代理机构 代理人
主权项
地址 South San Francisco CA US