RADIOACTIVE FLUORINE LABELING PRECURSOR COMPOUND AND METHOD FOR MANUFACTURING RADIOACTIVE FLUORINE LABELED COMPOUND USING THE SAME

摘要

There is provided a labeling precursor compound represented by the following general formula (2):;;wherein R1 represents an alkynyl group, an alkynyloxy group, an azide group, an azidoalkyl group, an arylazide group, a monocyclic or condensed polycyclic aryl group or a nitrogen-containing heterocycle; R2 and R3 each independently represent an alkyl group or a hydroxyalkyl group which hydroxy group may be protected with a protecting group, and n is an integer of 1 or 2; R6 represents an alkyl group or —CONR11R12 wherein R11 and R12 each independently represent an alkyl group or a monocyclic or condensed polycyclic aryl group; and R4, R5, R7 and R8 each independently represent a hydrogen atom, an alkyl group or an alkoxy group.

主权项

1. A labeling precursor compound of a radioactive fluorine-labeled compound represented by the following general formula (1):wherein R1 represents an alkynyl group, an alkynyloxy group, an azide group, an azidoalkyl group, an arylazide group, a substituted or unsubstituted monocyclic or condensed polycyclic aryl group, or a substituted or unsubstituted nitrogen-containing heterocycle; R2 and R3 each independently represent an alkyl group having 1 to 6 carbon atoms, or a hydroxyalkyl group having 1 to 6 carbon atoms which hydroxy group may be protected with a protecting group; and n is an integer of 1 or 2,
which is represented by the following general formula (2):wherein R1, R2, R3 and n are the same as those in the above-described general formula (1); R6 represents an alkyl group having 4 to 24 carbon atoms, or —CONR11R12 wherein R11 and R12 each independently represent an alkyl group having 1 to 24 carbon atoms, or a substituted or unsubstituted monocyclic or condensed polycyclic aryl group; and R4, R5, R7 and R8 each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms.