| 发明名称 |
PEPTIDE LIBRARIES |
| 摘要 |
The invention relates to a method for altering the conformational diversity of a first repertoire of polypeptide ligands, comprising a plurality of polypeptides comprising at least two reactive groups separated by a loop sequence covalently linked to a molecular scaffold which forms covalent bonds with said reactive groups, to produce a second repertoire of polypeptide ligands, comprising assembling said second repertoire from the polypeptides and structural scaffold of said first repertoire, incorporating one of the following alterations: (a) altering at least one reactive group; or (b) altering the nature of the molecular scaffold; or (c) altering the bond between at least one reactive group and the molecular scaffold; or (d) any combination of (a), (b) or (c). |
| 申请公布号 |
US2017067045(A1) |
申请公布日期 |
2017.03.09 |
| 申请号 |
US201615354667 |
申请日期 |
2016.11.17 |
| 申请人 |
BICYCLE THERAPEUTICS LIMITED |
发明人 |
Winter Gregory Paul;Heinis Christian;Bernard Elise;Loakes David;Teufel Daniel Paul |
| 分类号 |
C12N15/10;C07K1/00 |
主分类号 |
C12N15/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for altering the conformation of a first polypeptide ligand or group of polypeptide ligands, each polypeptide ligand comprising at least two reactive groups separated by a loop sequence covalently linked to a molecular scaffold which forms covalent bonds with said reactive groups, to produce a second polypeptide ligand or group of polypeptide ligands, comprising assembling said second ligand or group of ligands from the polypeptide(s) and structural scaffold of said first ligand or group of ligands, incorporating one of:
(a) altering at least one reactive group; or (b) altering the nature of the molecular scaffold; or (c) altering the bond between at least one reactive group and the molecular scaffold; or (d) any combination of (a), (b) or (c). |
| 地址 |
Cambridge GB |
