INJECTABLE STERILE AQUEOUS FORMULATION BASED ON CROSSLINKED HYALURONIC ACID AND HYDROXYAPATITE FOR AESTHETIC USE

摘要

The object of the present invention is an injectable sterile aqueous formulation, ready-to-use, resorbable, used for aesthetic purposes as a particulate, cohesive, viscoelastic gel comprising i) crosslinked hyaluronic acid, or one of its salts, at a concentration of between 0.1% and 4% (mass/volume); the crosslinking carried out providing the possibility of obtaining a gel based on crosslinked hyaluronic acid with a so-called cohesive structure, and ii) hydroxyapatite, at a concentration of between 5% and 60% (mass/volume), the hydroxyapatite being in the form of particles with an average size of less than or equal to 200 μm; the injectable sterile aqueous formulation having viscoelastic properties such that tan δ at the frequency of 1 Hz is less than or equal to 0.60.

主权项

1. An injectable sterile aqueous formulation in the form of a particulate cohesive viscoelastic gel comprising:
i) crosslinked hyaluronic acid, or a salt thereof, at a concentration of between 0.1% and 4% (mass/volume), and ii) hydroxyapatite at a concentration of between 5% and 60% (mass/volume), the hydroxyapatite being in the form of particles with an average size of less than or equal to 200 μm, wherein the injectable sterile aqueous formulation exhibits viscoelastic properties wherein the tan δ at the frequency of 1 Hz is less than or equal to 0.60.