ANTIMICROBIAL COMPOSITIONS AND METHODS AND USES THEREOF

摘要

The invention relates to inhibitors of a bacterial biofilm formation that target the N′ loop extension of the periplasmic subunit of a bacterial Phosphate Specific Transfer system (PstS), specifically, of P. aeruginosa. The inhibitors of the invention may be either derived from the N′ loop extension of PstS or directed against the N′ loop extension. The invention further provides compositions and methods using said inhibitors in inhibiting biofilm formation and in treating pathologic conditions associated therewith.

主权项

1. An inhibitor of a bacterial biofilm formation comprising at least one of:
(a) at least one amino acid sequence derived from the N′ loop extension of the periplasmic subunit of a bacterial Phosphate Specific Transfer system (PstS), any ortholog or of any fragment thereof, or any nucleic acid sequence encoding the same; and (b) at least one compound that specifically binds to said N′ loop extension of PstS.