Method and system for ABO antibody detection and characterization
摘要
The present application discloses a system and method for ABO antibody detection and characterization that can provide an alternative means for assessment and management of ABO incompatible and ABO-compatible transplants. The method and system comprises determining an anti-ABO blood group antigen subtype antibody profile of a subject using a biological sample from the subject. The method and system can be used to evaluate the suitability of a donor blood or tissue product for a recipient subject by comparing the determined anti-ABO antigen subtype antibody profile of the recipient subject with the ABO histo-blood group or ABO histo-blood subgroup of a donor blood or tissue product. In order to define the subject's ABO histo blood subgroup, the determined antibody profile is compared to known ABO histo-blood group antigen subtype profiles and/or known anti-ABO antigen subtype antibody profiles for ABO histo-blood subgroups to identify the ABO histo-blood subgroup of the subject.
申请公布号
AU2017201012(A1)
申请公布日期
2017.03.09
申请号
AU20170201012
申请日期
2017.02.15
申请人
The Governors of the University of Alberta
发明人
LOWARY, Todd Lambert;CAIRO, Christopher Warren;WEST, Lori Jeanne;BURIAK, Jillian Mary;MELONCELLI, Peter John;JEYAKANTHAN, Mylvaganam;SLANEY, Anne Margaret