| 发明名称 |
CHIMERIC ANTIGEN RECEPTOR |
| 摘要 |
Provision of a chimeric antigen receptor (CAR) comprising a disialoganglioside (GD2)-binding domain which comprises a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences: b) a light chain variable region (VL) having CDRs with the following sequences: T cells expressing such a CAR are useful in the treatment of some cancers. |
| 申请公布号 |
US2017066838(A1) |
申请公布日期 |
2017.03.09 |
| 申请号 |
US201515123331 |
申请日期 |
2015.03.06 |
| 申请人 |
UCL BUSINESS PLC |
发明人 |
Pulé Martin;Anderson John;Thomas Simon |
| 分类号 |
C07K16/30;C12N15/85;A61K39/395;A61K38/17;C07K14/705;C07K14/725 |
主分类号 |
C07K16/30 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A chimeric antigen receptor (CAR) comprising a disialoganglioside (GD2)-binding domain further comprising
a) a heavy chain variable region (VH) having complementarity determining regions (CDRs) with the following sequences:CDR1-(SEQ ID No. 1)SYNIH;CDR2-(SEQ ID No. 2)VIWAGGSTNYNSALMSCDR3-(SEQ ID No. 3)RSDDYSWFAY;and
b) a light chain variable region (VL) having CDRs with the following sequences:CDR1-(SEQ ID No. 4)RASSSVSSSYLH;CDR2-(SEQ ID No. 5)STSNLASCDR3-(SEQ ID No. 6)QQYSGYPIT. |
| 地址 |
London GB |
