| 发明名称 |
SOLID FORMS OF A FLAVIVIRIDAE VIRUS INHIBITOR COMPOUND AND SALTS THEREOF |
| 摘要 |
Provided herein are crystalline and salt forms of methyl N-{(1R)-2-[(2S)-2-{5-[4-(6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl} pyrrolidin-2-yl]-3H-benzimidazol-5-yl}thieno[3,2-b]thiophen-3-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-2-oxo-1-phenylethyl} carbamate, a Flaviviridae, including hepatitis C, virus inhibitor, pharmaceutical compositions comprising the compound, and processes of preparation thereof. Also provided are methods of its use for the treatment of a Flaviviridae, including HCV, infection in a subject in need thereof. |
| 申请公布号 |
US2017066779(A1) |
申请公布日期 |
2017.03.09 |
| 申请号 |
US201515123170 |
申请日期 |
2015.03.04 |
| 申请人 |
IDENIX Pharmaceuticals LLC |
发明人 |
Moussa Adel M.;Mayes Benjamin Alexander;Stewart Alistair James |
| 分类号 |
C07D495/04;A61K31/4184;A61K45/06 |
主分类号 |
C07D495/04 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A crystalline form of a compound of methyl N-{(1R)-2-[(2S)-2-{5-[4-(6-{2-[(2S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-3H-benzimidazol-5-yl}thieno[3,2-b]thiophen-3-yl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate of Formula I |
| 地址 |
Cambridge MA US |
