TREATMENT OF INTERVERTEBRAL DISC DEGENERATION USING HUMAN UMBILICAL CORD TISSUE-DERIVED CELLS

摘要

Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.

主权项

1. A method of treating a disease or condition related to intervertebral disc degeneration in a subject having a degenerated intervertebral disc comprising administering an isolated homogeneous population of cells obtained from human umbilical cord tissue into the degenerated intervertebral disc, wherein the umbilical cord tissue is substantially free of blood, wherein the isolated homogeneous population of cells is capable of self-renewal, and wherein the isolated homogeneous population of cells further has the following characteristics:
a. does not produce CD31, CD34, CD117, telomerase and HLA-DR; b. expresses CD10, CD13, CD44, CD73, and CD90; and c. expresses, relative to a human fibroblast, mesenchymal stem cell, or iliac crest bone marrow cell, increased levels of interleukin 8 and reticulon 1.