ATTENUATION-BASED OPTIC NEUROPATHY DETECTION WITH THREE-DIMENSIONAL OPTICAL COHERENCE TOMOGRAPHY

摘要

Optical coherence tomography (OCT) scan data of a subject is acquired over a region of interest which can include an optic disc or a macula of a retina. Layer boundaries of retinal layers are identified in the OCT scan data to facilitate measurements. In one aspect, a measurement related to ratio value between a total backscattered signal intensity of one or more target layers of the retina and a total backscattered signal intensity of one or more reference layers is computed on a location-by-location basis within a region of interest of the OCT scan data. Measurements can be collected, aggregated, analyzed, and displayed in connection with other information taken or derived from the OCT scan data.

主权项

1. A method for detecting and monitoring an optic neuropathy of a retina, comprising:
determining for at least a portion of the retina, a set of ratio values (R) between a total backscattered signal intensity from one or more target layers of the retina and a total backscattered signal intensity from one or more reference layers of the retina; and determining for at least the portion of the retina, a set of integrated attenuation values (μATTd) related to the set of ratio values, wherein each ratio value is used as a proxy measurement for determining a corresponding integrated attenuation value, whereinμATTd=log(R/β+1)2,where
β is modeled as a substantially constant value, R is the ratio value, and μATTd represents a total attenuation of light over a depth d of the retina.