THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH ACCUMULATION OF ABNORMAL SUBSTANCES IN CELLS, BIOMARKER, DIAGNOSTIC AGENT, AND SCREENING METHOD

摘要

Provided is a therapeutic agent for diseases associated with the accumulation of abnormal substances in cells which contains, as an active ingredient, a substance for suppressing the expression of ERdj8, or a substance for suppressing an autophagy activity suppression function which ERdj8 has. Further provided is a biomarker for detecting diseases associated with the accumulation of abnormal substances, which comprise ERdj8in, in cells. Further provided is a diagnostic agent for use in the detection of diseases associated with the accumulation of abnormal substances in cells, which includes substances which specifically bind to ERdj8. Further provided is a method for screening candidate substances for the therapeutic agent for diseases associated with the accumulation of abnormal substances in cells, having serve as an indicator (a) activity of ERdj8 for suppressing the autophagy activity suppression function, or (b) activity for suppressing the expression amount of ERdj8, which a substance to be tested has.