主权项 |
1. A method of determining the response of a patient suffering from asthma or a respiratory disorder to a therapy comprising a TH2 pathway inhibitor, the method comprising:
obtaining a biological sample from the patient, measuring the mRNA level of at least one, at least two, or at least three markers in the sample selected from CSF1, MEIS2, LGALS12, IDO1, THBS4, OLIG2, ALOX15, SIGLEC8, CCL23, PYROXD2, HSD3B7, SORD, ASB2, CACNG6, GPR44, MGAT3, SLC47A1, SMPD3, CCR3, CLC, CYP4F12, and ABTB2, comparing the mRNA level detected in the sample to a reference level, anddetermining that the patient will respond to the therapy when the mRNA level measured in the sample is elevated compared to the reference level and predicting that the patient will not respond to the therapy when the mRNA level measured in the sample is reduced compared to the reference level. |