| 发明名称 |
MONOCLONAL ANTIBODY AGAINST HUMAN PRPC AND USE THEREOF |
| 摘要 |
A monoclonal antibody against human PrPc protein capable of reducing the expression level of transcription factor Twist1 in a targeting mode and inducing macrophage and NK cells to target to rectal cancer tumor cells. The combined drug therapy with the antibody and cetuximab also exhibits inhibitory effect on tumor better than administration of the antibody or cetuximab alone. |
| 申请公布号 |
US2017066817(A1) |
申请公布日期 |
2017.03.09 |
| 申请号 |
US201615351418 |
申请日期 |
2016.11.14 |
| 申请人 |
Institute of Zoology, Chinese Academy of Sciences |
发明人 |
Chen Quan;Li Baowei;Hang Haiying;Du Lei;Wang Jun;Wang Xiaohui |
| 分类号 |
C07K16/18;G01N33/577;C07K16/32;C07K16/30;C07K16/28 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A monoclonal Ab-5 antibody, which specifically binds to human cellular prion protein (PrPc). |
| 地址 |
Beijing CN |
