HUMANIZED IL-7 RODENTS

摘要

Genetically modified non-human animals comprising a human or humanized interleukin-7 (IL-7) gene. Cells, embryos, and non-human animals comprising a human or humanized IL-7 gene. Rodents that express human or humanized IL-7 protein. Genetically modified mice that comprise a human or humanized IL-7-encoding gene in their germline, wherein the human or humanized IL-7-encoding gene is under control of endogenous mouse IL-7 regulatory sequences.

主权项

1. An isolated cell obtained from a genetically modified rodent, wherein the genome of the cell and the genome of the rodent comprise a humanized IL-7 gene, wherein the humanized IL-7 gene comprises human IL-7 exons 2, 3, 4, 5, and 6, and is operably linked to endogenous rodent IL-7 5′ regulatory sequences, wherein the rodent is a mouse or a rat, and wherein the IL-7 protein encoded by the humanized IL-7 gene is expressed in the serum of the rodent.