发明名称 |
HUMANIZED ANTIBODIES THAT BIND LGR5 |
摘要 |
Disclosed herein are humanized anti-LGR5 antibodies for the treatment of cancer. Antibodies disclosed herein may bind LGR5 without disrupting LGR5-RSPO1 binding or signaling, and may disrupt LGR5 signaling through Wnt that is independent of RSPO1. Also disclosed are heavy and light chain polypeptide sequences for the biding of LGR5, for example without disrupting LGR5-RSPO binding or signaling. |
申请公布号 |
US2017114145(A1) |
申请公布日期 |
2017.04.27 |
申请号 |
US201615379058 |
申请日期 |
2016.12.14 |
申请人 |
Bionomics Inc. |
发明人 |
Reyes Christopher L.;Chu Peter;Smith Kristen M.;Campbell Lioudmila A.;Shojaei Farbod;Norton John Thomas |
分类号 |
C07K16/30;A61K45/06;A61K31/337;A61K31/519;A61K31/513;A61K31/4745;A61K39/395;A61K31/7068 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
San Diego CA US |