| 发明名称 |
18-20 MEMBER BI-POLYCYCLIC COMPOUNDS |
| 摘要 |
The invention relates to 18-20 member bi-polycyclic compounds, methods of making these compounds, and methods of using them in treating hyperproliferative disorders (e.g., cancer) and non-malignant tumors; promoting muscle formation; inhibiting muscle degeneration or the loss of muscle mass or muscle function; and myofibers ex vivo. |
| 申请公布号 |
US2017114019(A1) |
申请公布日期 |
2017.04.27 |
| 申请号 |
US201515316029 |
申请日期 |
2015.06.04 |
| 申请人 |
HARO PHARMACEUTICAL INC. ;THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY ;UNIVERSITE DE MONTREAL |
发明人 |
Bettoun David;Martinez Eduardo;Gleason James;Mader Sylvie;Xing Shuo |
| 分类号 |
C07D215/54;C07D209/08;C07C259/10;C07D209/42 |
主分类号 |
C07D215/54 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound of Formula I:
A-W—Z (I)or a pharmaceutically acceptable salt thereof, wherein
A is W is a heterocyclylene, arylene, heteroarylene, alkenylenearylene, arylenealkenylene alkenyleneheteroarylene, or heteroarylenealkenylene; and Z is a hydrogen bond donor, with the proviso that the compound is notwhere R is —OH, —OCH3 and —NHOH; and R′ is —OH or —OCH3. |
| 地址 |
Merion Station PA US |
