| 发明名称 |
IONIZABLE CATIONIC LIPID FOR RNA DELIVERY |
| 摘要 |
What is described is a compound of formula III or IV;wherein
R1 is a branched alkyl with 12 to 20 carbons;R2 is a linear alkyl with 5 to 10 carbons or a branched alkyl with 12 to 20 carbons;L1 and L2 are each a bond or a linear alkylene having 1 to 3 carbon atoms, when L3 is a bond;L1 and L2 are each a linear alkylene or alkenylene 5 to 18 carbon atoms, when L3 is an alkylene of 5 to 18 carbons;X is S or O;R3 is of a lower alkyl; andR4 and R5 are the same or different, each a lower alkyl;or a pharmaceutically acceptable salt thereof. |
| 申请公布号 |
US2017114010(A1) |
申请公布日期 |
2017.04.27 |
| 申请号 |
US201715400691 |
申请日期 |
2017.01.06 |
| 申请人 |
Arcturus Therapeutics, Inc. |
发明人 |
Payne Joseph E.;Chivukula Padmanabh |
| 分类号 |
C07C333/04;C07C235/12;C12N15/113;A61K47/20;A61K47/18;C07C323/25;C07C271/22 |
主分类号 |
C07C333/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound of formula III or IVwherein
R1 is a branched alkyl with 12 to 20 carbons, R2 is a linear alkyl with 5 to 10 carbons or a branched alkyl with 12 to 20 carbons, L1 and L2 are each a bond or a linear alkyl having 1 to 3 carbon atoms, X is S or O, L3 is a bond, R3 is of a lower alkyl, and R4 and R5 are the same or different, each a lower alkyl;or a pharmaceutically acceptable salt thereof. |
| 地址 |
San Diego CA US |
