PROGRAMMABLE UNIVERSAL CELL RECEPTORS AND METHOD OF USING THE SAME

摘要

The present invention provides programmable universal cell receptors (PUCRs) comprising a catalytic antibody region, a transmembrane domain and a cytoplasmic domain. The PUCRs disclosed herein may be conjugated to a specificity agent in order to program the receptor for specificity to any molecule of interest. Also provided are nucleic acids encoding such PUCRs, and cells expressing the PUCRs. Such cells may be used in treating a variety of medical conditions and diseases including cancer and infectious diseases.

主权项

1. An isolated nucleic acid sequence encoding a programmable universal cell receptor, wherein said programmable universal cell receptor comprises:
a. a catalytic antibody, or a catalytic portion thereof, comprising a reactive amino acid residue; b. a transmembrane domain; and c. an intracellular domain.