AGONISTS OF NEUROTROPHIN RECEPTORS AND THEIR USE AS MEDICAMENTS

摘要

The invention relates to compounds of Formula I:;;and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, and R3 are defined as set forth in the specification. The compounds are agonists of neurotrophin (such as nerve growth factor) receptors.

主权项

1. A compound having Formula I: or a pharmaceutically acceptable salt or prodrug thereof, wherein: R1 is phenyl substituted with halogen or trifluoromethyl, and further optionally substituted with one or two substituents selected from the group consisting of halogen, C1-6 alkyl, (C1-6)alkoxy, and halo(C1-6)alkyl; or R1 is pyrrolidin-1-yl; R2 is 2-oxo-pyrrolidin-1-ylmethyl or sulfamoylphenyl; and R3 is chosen from propyl, 1-methylethyl, butyl, 2-methylpropyl, pentyl, 1-methylbutyl, 2-methylbutyl, hexyl, 4-methylpentyl, 3-methylpentyl, 2-methylpentyl, and 1-methylpentyl.