| 发明名称 |
High Affinity Antibodies That Neutralize Staphylococcus Enterotoxin B |
| 摘要 |
Provided herein are antibodies that specifically bind and neutralize Staphylococcus enterotoxin B. In addition, nucleic acids encoding such antibodies, and cells that express such antibodies are provided. Also provided are methods for treating diseases mediated by, and for neutralizing Staphylococcus enterotoxin B. |
| 申请公布号 |
US2017121396(A1) |
申请公布日期 |
2017.05.04 |
| 申请号 |
US201615144334 |
申请日期 |
2016.05.02 |
| 申请人 |
Morphotek, Inc. |
发明人 |
Sass Philip M.;Nicolaides Nicholas C.;Grasso Luigi;Berger Marc;Sai Tao |
| 分类号 |
C07K16/12 |
主分类号 |
C07K16/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A recombinant antibody, said antibody comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO: 92, a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 93, and a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 94, a light chain CDR1 comprising the amino acid sequence of SEQ ID NO: 80, a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 81, and a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 82, or an antigen-binding fragment thereof, that binds to Staphylococcus enterotoxin B with a dissociation constant (KD) of less than 3×10−8 M. |
| 地址 |
Exton PA US |
