| 发明名称 |
MEDICAMENT FOR PREVENTING AND/OR TREATING STRESS DISEASES |
| 摘要 |
The present invention relates to a medicament for preventing and/or treating stress diseases, said medicament being characterized in that (1S)-2-acetyl-1-(4-chloro-2-methoxyphenyl)-5-fluoro-1,2,3,9-tetrahydrospiro[β-carboline-4,1′-cyclopropane] is administered at such a specific dose that a brain TSPO occupancy requiring for expressing the pharmacological effects of the medicament can be obtained. |
| 申请公布号 |
US2017119742(A1) |
申请公布日期 |
2017.05.04 |
| 申请号 |
US201515317506 |
申请日期 |
2015.06.11 |
| 申请人 |
ONO PHARMACEUTICAL CO., LTD. |
发明人 |
KATSUMATA Seishi;MITSUI Katsukuni |
| 分类号 |
A61K31/437;A61K9/00;A61K51/04 |
主分类号 |
A61K31/437 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A medicament for preventing and/or treating stress diseases, comprising (1S)-2-acetyl-1-(4-chloro-2-methoxyphenyl)-5-fluoro-1,2,3,9-tetrahydrospiro[β-carboline-4,1′-cyclopropane] represented by formula in an amount such that upon administration to a patient, TSPO occupancy in the patient reaches about 50 to about 85% per dose. |
| 地址 |
Osaka JP |
