INCREASED EFFECTIVENESS OF ALLYLAMINE DRUG COMPOUNDS FOR TOPICAL TREATMENT OF FUNGAL INFECTIONS OF THE SKIN AND SKIN APPENDAGES

摘要

The invention is an increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages. The allylamine active ingredient is prepared in an acidic environment; the acidic environment altering the physiochemical properties of the active ingredient resulting in the active ingredient having a positive charge. The positive charge and enhancers used in the formula allow for increased penetration of the active ingredient through skin and skin appendages. The positively charged active ingredients are either dissolved in the vehicle directly or dissolved in a plurality of beads suspended in the vehicle. The bead structure minimizes the molecular diffusion of the positively charged active ingredient and a catalytic species through the bead structure, thus stabilizes the positively charged active ingredient inside the bead by impeding the interaction of the positively charged active ingredient and the catalytic species, and thereby extending the shelf life of the positively charged active ingredient.

主权项

1. An increased effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages comprising:
a mixture of an active ingredient dissolved in a solubilizer in a closed system added to an acidic environment, an enhancer, an antioxidant, a preservative, a humectant, and a viscosity increasing agent; the acidic environment altering the physiochemical properties of the active ingredient to form a positively charged active ingredient and combined with the enhancer to increase effectiveness of allylamine drug compounds for topical treatment of fungal infections of skin and skin appendages; wherein the mixture is added to a vehicle and further contained in a storage container or transferred to a dispenser for application.