METHODS AND COMPOSITIONS FOR ASSESSING PREDICTING RESPONSIVENESS TO A TNF INHIBITOR

摘要

Methods, systems (e.g., computer systems), compositions, and kits are provided for predicting whether an individual will respond to treatment with a TNF inhibitor, for determining a treatment regimen for an individual (e.g. a therapy that does or does not include administration of a TNF inhibitor), and for treating an individual. The subject methods include measuring an expression level of an RGS1 expression product and/or an expression level of an IL11 expression product in a biological sample from an individual. In some cases, the methods include a step of calculating a TNF inhibitor signature score from measured expression levels (e.g., calculating a geometric mean of the expression levels of an RGS1 expression product and an IL11 expression product). After comparing measured expression levels and/or a calculated TNF inhibitor signature score with a reference, one can predict whether an individual will respond to treatment with a TNF inhibitor.

主权项

1. A method for predicting whether an individual will respond to treatment with a TNF inhibitor, the method comprising:
(a) measuring an expression level of an RGS1 expression product and an expression level of an IL11 expression product in a biological sample from an individual; (b) calculating a geometric mean of said measured expression levels to obtain a TNF inhibitor signature score for the individual; and (c) generating a report that includes the TNF inhibitor signature score and a reference value for the TNF inhibitor signature score.