发明名称 HETEROBICYCLICALLY SUBSTITUTED 4-OXOBUTANE ACID DERIVATIVES AND USE THEREOF
摘要 The present application relates to novel heterobicyclically substituted 4-oxobutanoic acid derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of respiratory, pulmonary and cardiovascular disorders.
申请公布号 US2017121315(A1) 申请公布日期 2017.05.04
申请号 US201515317519 申请日期 2015.06.08
申请人 BAYER PHARMA AKTIENGESELLSCHAFT 发明人 BECK Hartmut;LI Volkhart Min-Jian;CANCHO GRANDE Yolanda;TIMMERMAN Andreas;BROHM Dirk;JÖRIßEN Hannah;BOGNER Pamela;GERISCH Michael;LANG Dieter
分类号 C07D405/06;A61K31/53;C07D409/06;C07D413/14;C07D409/14;C07D413/06;A61K45/06;C07D405/14 主分类号 C07D405/06
代理机构 代理人
主权项 1. Compound of the formula (I) in which Het represents bicyclic heteroaryl of the formula in which * labels the linkage to the R1O group and ** labels the linkage to the carbonyl group, R1 represents (C1-C8)-alkyl which can be substituted with cyano or up to six times with fluorine, orrepresents a group of the formula in which *** labels the linkage to the O atom,L represents —CH2—, —CH2—CH2—, —C(═O)—CH2—*** or —CH2—CH2—CH2—andCy represents (C3-C6)-cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, phenyl, thienyl, pyridyl or 2,1,3-benzoxadiazolyl, where (C3-C6)-cycloalkyl, oxetanyl, tetrahydrofuranyl and tetrahydropyranyl can be mono- or disubstituted, identically or differently, with a radical selected from the group fluorine and methylandwhere phenyl, thienyl and pyridyl can be mono- or disubstituted, identically or differently, with a radical selected from the group fluorine, chlorine, cyano, methyl, difluoromethyl, trifluoromethyl, methoxy, ethoxy, trifluoromethoxy, (trifluoromethyl)sulphanyl, methylsulphonyl, aminocarbonyl, methoxycarbonylamino and 2-oxo-1,3-oxazolidin-3-yl, R2A and R2B both represent hydrogen or are linked with one another and together form a —CH2CH2 bridge and R3 represents hydrogen or a substituent selected from the group fluorine, methyl, fluoromethyl, difluoromethyl and trifluoromethyl, where such a substituent can be bonded in the designated position 5, 6, 7 or 8, and the salts, solvates and solvates of the salts thereof.
地址 Berlin DE