| 发明名称 |
DENDRIMER COMPOSITIONS AND USE IN TREATMENT OF NECROTIZING ENTEROCOLITIS AND OTHER GASTROINTESTINAL DISORDERS |
| 摘要 |
A dendrimer formulation, such as a PAMAM dendrimer or a multiarm PEG polymeric formulation has been developed for oral administration to the gastrointestinal tract for treatment of inflammatory diseases associated with infection or cancer. In the preferred embodiment, the dendrimers are in the form of dendrimer nanoparticles comprising poly(amidoamine) (PAMAM) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for treatment of one or more symptoms of necrotizing enterocolitis. |
| 申请公布号 |
US2017119897(A1) |
申请公布日期 |
2017.05.04 |
| 申请号 |
US201615339606 |
申请日期 |
2016.10.31 |
| 申请人 |
The Johns Hopkins University |
发明人 |
Hackam David;Kannan Sujatha;Rangaramanujam Kannan;Nino Diego F.;Zhang Fan |
| 分类号 |
A61B10/00;A61K49/00;A61K9/00;A61K31/19 |
主分类号 |
A61B10/00 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for treating a gastrointestinal disorder characterized by inflammation and infection or cancer comprising orally administering to the subject, a pharmaceutically acceptable composition comprising dendrimer complexed to one or more therapeutic, prophylactic or diagnostic agent for treatment or diagnosis of the disorder. |
| 地址 |
Baltimore MD US |
