| 发明名称 |
PROCESS FOR MAKING AN ASYMMETRIC FLUOROPHORE |
| 摘要 |
The present invention relates to a process for making an asymmetric fluorophore. The asymmetric fluorophore is useful as a stain for staining live cells or fixed cell and provides whole-cell staining of such cells. |
| 申请公布号 |
US2017121599(A1) |
申请公布日期 |
2017.05.04 |
| 申请号 |
US201615294065 |
申请日期 |
2016.10.14 |
| 申请人 |
UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE |
发明人 |
ARNATT CHRISTOPHER;ELLIOTT JOHN |
| 分类号 |
C09K11/06;C07F5/02;G01N1/30 |
主分类号 |
C09K11/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for making an asymmetric fluorophore, the process comprising:
decarboxylating a compound of formula 1to form a compound of formula 2 condensing the compound of formula 2 with 2-pyrrole aldehyde to form a compound of formula 3 difluorinating the compound of formula 3 in a presence of boron trifluoride ethyl etherate to form a compound of formula 4 hydrolyzing the compound of formula 4 to form a compound of formula 5and
succinimating the compound of formula 5 to form the asymmetric fluorophore comprising a compound of formula 6 |
| 地址 |
Gaithersburg MD US |
