发明名称 |
Aldehyde Tags, Uses Thereof in Site-Specific Protein Modification |
摘要 |
The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as a chemical handle for site-specific attachment of a moiety of interest to a polypeptide. |
申请公布号 |
US2017121389(A1) |
申请公布日期 |
2017.05.04 |
申请号 |
US201615238158 |
申请日期 |
2016.08.16 |
申请人 |
The Regents of the University of California |
发明人 |
Carrico Isaac S.;Carlson Brian L.;Wu Peng;Bertozzi Carolyn Ruth |
分类号 |
C07K16/00;A61K38/18;A61K38/21;A61K39/00;A61K38/45;A61K38/37 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Oakland CA US |