发明名称 |
GANIRELIX PRECURSOR AND METHOD FOR PREPARING GANIRELIX ACETATE BY USING THE SAME |
摘要 |
Disclosed is a method for preparing ganirelix acetate. The method includes the following steps: respectively replacing Fmoc-HArg(Et)2-OH and Fmoc-D-HArg(Et)2-OH by employing Fmoc-Lys(Boc)-OH and Fmoc-D-Lys(Boc)-OH or Fmoc-Lys(Alloc)-OH and Fmoc-D-Lys(Alloc)-OH; synthesizing a ganirelix precursor I or ganirelix precursor II-peptide resin in advance; and then respectively performing modifications and treatments on side chain amino groups of Lys and D-Lys in the precursor I or the precursor II-peptide resin to obtain ganirelix acetate. The ganirelix acetate synthesized therefrom is high in purity, has few impurities and a relatively low cost, and is suitable for large-scale production. |
申请公布号 |
US2017121371(A1) |
申请公布日期 |
2017.05.04 |
申请号 |
US201515318356 |
申请日期 |
2015.06.12 |
申请人 |
HYBIO PHARMACEUTICAL CO., LTD. |
发明人 |
CHEN Youjin;LIU Jian;MA Yaping;YUAN Jiancheng |
分类号 |
C07K7/23;C07K1/107 |
主分类号 |
C07K7/23 |
代理机构 |
|
代理人 |
|
主权项 |
1. A ganirelix precursor I having a structure as shown below:
Ac-D-2-Nal-D-Phe(4-Cl)-D-3-Pal-Ser-Tyr-D-Lys-Leu-Lys-Pro-D-Ala-NH2. |
地址 |
Shenzhen CN |