| 主权项 |
1. A compound having the structural formula (A):or a pharmaceutically acceptable salt thereof, wherein:
ring A is an aryl or heteroaryl ring; each of X1 and X2 is independently selected from N and C(R6); each of Y1 and Y2 is independently selected from —CH2— and —O—, wherein no more than one of Y1 or Y2 is —O—; each R1 and each R7 is independently selected from selected from C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, halo, C1-C6 heteroalkyl, cycloalkyl, aryl, heteroaryl, aryloxy, aralkyl, heterocyclyl, heterocyclylalkyl, nitro, cyano, —C(O)R, —OC(O)R, —C(O)OR, —(C1-C6 alkylene)-C(O)R, —SR, —S(O)2R, —S(O)2—N(R)(R), —(C1-C6 alkylene)-S(O)2R, —(C1-C6 alkylene)-S(O)2—N(R)(R), —N(R)(R), —C(O)—N(R)(R), —N(R)—C(O)R, —N(R)—C(O)OR, —(C1-C6 alkylene)-N(R)—C(O)R, —N(R)S(O)2R, and —P(O)(R)(R); wherein each of alkyl, alkenyl, alkynyl, alkoxy, heteroalkyl, cycloalkyl, aryl, heteroaryl, aryloxy, aralkyl, heterocyclyl, and heterocyclylalkyl is independently substituted with 0-5 occurrences of Ra; or two R1 or two R7 are taken together with the carbon atoms to which they are attached form a cycloalkyl or heterocyclyl ring independently substituted with 0-5 occurrences of Rb; each of R2, if present, R3a, R3b, R4, R8a and R8b is independently selected from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halo, hydroxyl, C1-C6 heteroalkyl, and —N(R)(R); wherein each alkyl, alkoxy, and heteroalkyl is optionally and independently substituted with 0-5 occurrences of Ra; each of R5 and R9 is independently selected from hydrogen, C1-C6 alkyl, and C1-C6 heteroalkyl; wherein each alkyl and heteroalkyl is optionally and independently substituted with 0-5 occurrences of Ra; each R6 is independently selected from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halo, C1-C6 heteroalkyl, and —N(R)(R); wherein each alkyl, alkoxy, and heteroalkyl is optionally and independently substituted with 0-5 occurrences of Ra; each R is independently selected from hydrogen, hydroxyl, halo, thiol, C1-C6 alkyl, C1-C6 thioalkyl, C1-C6 alkoxy, C1-C6 heteroalkyl, cycloalkyl, cycloalkylalkyl, heteroarylalkyl, heterocyclyl, and heterocyclylalkyl, wherein each of alkyl, thioalkyl, alkoxy, heteroalkyl, cycloalkyl, cycloalkylalkyl, heteroarylalkyl, heterocyclyl, and heterocyclylalkyl is independently substituted with 0-5 occurrences of Ra, or 2R1 together with the atom(s) to which they are attached form a cycloalkyl or heterocyclyl ring independently substituted with 0-5 occurrences of Rb; each Ra and each Rb is independently selected from C1-C6 alkyl, halo, hydroxyl, C1-C6 heteroalkyl, C1-C6 alkoxy, cycloalkyl, heterocyclyl, or cyano, wherein each of alkyl, heteroalkyl, alkoxy, cycloalkyl and heterocyclyl is independently substituted with 0-5 occurrences of R′; each R′ is independently selected from C1-C6 alkyl, C1-C6 heteroalkyl, halo, hydroxyl, cycloalkyl or cyano; or 2R′ together with the atom(s) to which they are attached form a cycloalkyl or heterocyclyl ring; represents a single or double bond; m is 0, 1, or 2; n is 0, 1, 2, or 3; and each o is 0 when is a double bond; and each o is 1 when is a single bond. |
