发明名称 |
NITROGEN-CONTAINING HETEROCYCLIC COMPOUND |
摘要 |
The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as a medicament such as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder, Parkinson's disease dementia, dementia with Lewy bodies and the like, and the like. The present invention relates to a compound represented by the formula (I) or a salt thereof.;;wherein each symbol is as described in the attached DESCRIPTION. |
申请公布号 |
US2017121308(A1) |
申请公布日期 |
2017.05.04 |
申请号 |
US201515318552 |
申请日期 |
2015.06.11 |
申请人 |
Takeda Pharmaceutical Company Limited |
发明人 |
OGINO Masaki;KIMURA Eiji;SUZUKI Shinkichi;ASHIZAWA Tomoko;IMAEDA Toshihiro;FUJIMORI Ikuo;ARAI Ryosuke |
分类号 |
C07D401/10;C07D213/81;C07D405/14 |
主分类号 |
C07D401/10 |
代理机构 |
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代理人 |
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主权项 |
1. A compound represented by the formula (I):wherein
A is a cyclic group which is optionally further substituted; R1 is a hydrogen atom or a hydroxyl group; R2 and R3 are each independently a hydrogen atom, a halogen atom, a cyano group, an optionally substituted C1-6 alkyl group, an optionally substituted C2-6 alkenyl group, an optionally substituted C3-6 cycloalkyl group, or an optionally substituted C1-6 alkoxy group; R4 is a hydrogen atom or a halogen atom; R5 is an optionally substituted 5- or 6-membered aromatic heterocyclic group, a halogen atom, a cyano group, an optionally substituted C1-6 alkyl group, or an optionally substituted C1-6 alkoxy group; and X is CH or N,or a salt thereof. |
地址 |
Osaka-shi, Osaka JP |