COMPOUNDS INFLUENCING FATTY ACID UPTAKE AND METABOLISM AND THE PRODUCTION OF INFLAMMATORY AGENTS AND METHODS OF ISOLATING THEM FROM COCOA PRODUCTS

摘要

The invention provides compounds and plant extract compositions that inhibit pancreatic enzymes, such as lipases and amylases, and most particularly pancreatic lipase and phospholipase A2 (PLA2), and COX-2 enzyme, and improve the inflammatory state or response conditions in animals. The compounds and plant extracts can be used in methods and administration regimens to treat animals for obesity-related conditions, diabetes and related conditions, metabolic syndrome, metabolic endotoxemia, and inflammatory conditions. The compounds and plant extracts can also be used to produce comestible compositions to be incorporated into a normal diet to improve health or prevent or reduce the uptake of free fatty acids during digestion or the production of inflammatory eicosanoids or cytokines. The inhibitor compounds and compositions include cocoa-derived polymers of epicatechin, such as epicatechin-rich polymers of 2 units through polymers of 14 units, or 5 to 14 units, and combinations of them.

主权项

1. A method of inhibiting fatty acid uptake in an animal comprising administering a comestible composition containing an effective amount of cocoa-derived epicatechin polymers from 2-14 units, wherein the activity of phospholipase A2 or pancreatic lipase enzyme is inhibited by 50% or more.